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Specifically, omega-3 PUFAs contribute to reducing CNS levels of critical inflammatory mediators like TNF-, cyclooxygenase-2/NO synthase, and IL-1

Osteoarthritis Cartilage 19 , 11321141 (2011)

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Severe depression, suicidal risk, psychosis, mania, dangerous aggression, dehydration, malnutrition or kidney impairment require stabilization before chelation, prolonged fasting, extensive sauna or complex detoxification protocols

Mechanism Driving Adverse Events The same receptor activity that produces efficacy also generates the class's characteristic side-effect profile

Patients are usually advised to decrease sugar consumption, lower their intake of processed foods, and add more fruits, vegetables, and legumes to their diet